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Welcome to the THYME project
Welcome to the Temporal Histories of Your Medical Event (THYME) project.
The overarching long-term vision of our research is to create novel technologies for processing clinical free text. Such technologies will enable sophisticated and efficient indexing, retrieval and data mining over the ever increasing amounts of electronic clinical data. Processing free text poses a number of challenges to which the fields of Artificial intelligence, natural language processing and computer science in general have made advances. Methods for processing free text are informed by linguistic theory combined with the power of statistical inferencing. A key component to the next step, natural language understanding, is discovering events and their relations on a timeline. Temporal relations are of prime importance in biomedicine as they are intrinsically linked to diseases, signs and symptoms, and treatments. Understanding the timeline of clinically relevant events is key to the next generation of translational research where the importance of generalizing over large amounts of data holds the promise of deciphering biomedical puzzles.
The goal of our current proposal is to discover temporal relations from clinical free text through achieving four specific aims:
Specific Aim 1: Develop (1) a temporal relation annotation schema and guidelines for clinical free text based on TimeML, which will require extensions to Treebank, PropBank and VerbNet annotation guidelines to the clinical domain, (2) an annotated corpus (500K words of clinical narrative) following the temporal relations schema with additions to Treebank, PropBank and VerbNet, (3) a descriptive study comparing temporal relations in the clinical and general domains.
Specific Aim 2: Extend and evaluate existing methods and/or develop new algorithms for temporal relation discovery in the clinical domain. Component-level evaluation
Specific Aim 3: Integrate best method and/or a variety of methods for temporal relation discovery into the cTAKES and release as open source annotators in the pipeline. Functional testing. Dissemination activities.
Specific Aim 4: System-level evaluation. Test the functionality of the enhanced cTAKES on translational research use cases, e.g. the progression of colon cancer as documented in clinical notes and pathology reports, the progression of brain tumor as documented in radiology reports.
The methods we will use for the temporal relation discovery are based on machine learning, e.g., Support Vector Machine technology. Such methods require the annotation of a reference standard from which the computations are derived. The best methods will be released as part of the cTAKES for the larger community to use and contribute to. We will test the methods against biomedical queries.
The project described is supported by Grant Number R01LM010090 from the National Library Of Medicine. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Library Of Medicine or the National Institutes of Health.
The project period is October, 2010 - September, 2014.
Who We Are
- University of Colorado
- Martha Palmer (PI)
- Jim Martin
- Wayne Ward
- Steven Bethard
- William Styler
- Arrick Lanfranchi (through August, 2012)
- Anwen Fredricksen
- and several Lingustics and Computer Science graduate students
- Boston Childrens Hospital/Harvard Medical School
- Guergana Savova (PI)
- Dmitriy Dligach
- Timothy Miller
- Sameer Pradhan
- Sean Finan
- Chen Lin
- David Harris
- Jennifer Green
- Mayo Clinic
- Piet de Groen
- Brad Erickson
- James Masanz
- Donna Ihrke (through December, 2012)
- Pauline Funk
- Brandeis University
- James Pustejovsky
THYME annotation guidelines
will be posted soon
Annotations and availability
Annotation layers are treebank and propbank annotations as well as temporal annotations for events, temporal expressions and temporal relations. The corpus will be made available to the research community under a data use agreement. Instructions as to how to get the corpus will be posted soon.
Venues for manuscript submissions
Clinical Temporal Relations Annotation Guidelines - Release notes and latest versions
Annotations - Describes the corpus, the layers of annotations and annotation progress
Annotation Tools - Describes the progress and information pertaining to the Anafora annotation tool
Software - Describes the software modules and their organization
- Use this split for experiments with the THYME data (% 8)!
- Train sets: 1, 2, 3, 8, 9, 10, 11, 16, 17, 18, 19, 24, 25, 26, 27
- Development sets: 4, 12, 13, 20, 21
- Test sets: 6, 7, 14, 15, 22, 23
- Protege/Knowtator and Anafora annotation tools: annotations
- May 24, 2013 Methods meeting agenda and notes
- May 22, 2013 Agenda and notes
- May 17, 2013 Methods meeting agenda and notes
- May 9, 2013 Methods meeting agenda and notes
- May 8, 2013 Agenda and notes
- May 3, 2013 Methods meeting agenda and notes
- April 24, 2013 Agenda and notes
- April 10, 2013 Agenda and notes
- March 27, 2013 Agenda and notes
- March 13, 2013 Agenda and notes
- February 27, 2013 Agenda and notes
- February 13, 2013 Agenda and notes
- January 30, 2013 Agenda and notes
- January 28, 2013 (annotations subgroup) Agenda and notes
- January 16, 2013 Agenda and notes
- January 2, 2013 Agenda and notes
- December 19, 2012 Agenda and notes
- December 5, 2012 Agenda and notes
- November 21, 2012 Agenda and notes
- November 6, 2012 Agenda and notes
- October 24, 2012 Agenda and notes
- October 10, 2012 Agenda and notes
- September 12, 2012 Agenda and notes
- August 29, 2012 Agenda and notes
- August 15, 2012 Agenda and notes
- August 1, 2012 Agenda and notes
- July 18, 2012 Agenda and notes
- June 22, 2012 Agenda and notes
- June 20, 2012 Agenda and notes
- June 6, 2012 Agenda and notes
- May 23, 2012 Agenda and notes
- May 9, 2012 Agenda and notes
- April 25, 2012 Agenda and notes
- April 11, 2012 Agenda and notes
- March 28, 2012 Agenda and notes
- March 14, 2012 Agenda and notes
- Feb 29, 2012 Agenda and notes
- Feb 14, 2012 Agenda and notes
- Feb 1, 2012 Agenda and notes
If you need assistance and/or if you have questions about the project, feel free to send e-mail to steven.bethard at colorado dot edu OR Guergana.Savova at childrens dot harvard dot edu